Unfortunately this #PatchTuesday introduced another Lua script to Defenders signature DB that breaks loadlibrary even with trivial scan targets :( I started to track the issue in my fork:

https://github.com/v-p-b/loadlibrary/issues/2

The good news is I fixed the cert store so Authenticode with PCA 2024 will work. and you should still be able to experiment with e.g. the unpackers by disabling the Lua VM, as described here:

https://scrapco.de/blog/fuzzing-windows-defender-with-loadlibrary-in-2025.html#fuzzing